Don Aur Doctor

Nagarjuna Akkineni

(Deva)

Nani

(Das)

Rashmika Mandanna

(Pooja)

Aakanksha Singh

(Jahnavi)

Kunal Kapoor

(David)

Naveen Chandra

(Ajay)

Murali Sharma

(Murli Sharma)

Vennela Kishore

(Dr. Kuchipudi)

Rao Ramesh

(Dr. Bharadwaj)

Srinivas Avasarala

(Rajan)

R. Sarathkumar

(Dada)

Naresh

(Mohan)

Prudhviraj

(Jahnavi's manager)

S. P. Balasubramaniam

(Seetharamayya (Cameo Appearance))

Satya

(Das's Compunder)

Uttej

(Raju)

Sameer Hasan

(Doctor)

Prabhas Sreenu

(Seenu)

Raghu Karumanchi

(Local Rowdy)

Prabhakar

(Deva's henchman)

Sivannarayana Naripeddi

(Pooja's father)

Aishwarya Bhaskar

(Fishfry Lakshmi)

Satya Krishnan

(Das's sister-in-law)

Manobala

(Tata Rao, Pooja's assistant)

Sampoornesh Babu

(Actor (Cameo Appearance))